MOTS-c

MOTS-c is a sixteen-residue mitochondria-encoded peptide studied for its interactions with the folate cycle and AMPK activation in metabolic research.

Yes. 1 third party certificate for MOTS-c are published on this site, covering endotoxin, purity and sterility. Each one is the report as the testing laboratory issued it, not a retyped summary, and the most recent lot is 10mg · Nov 2025. Match the batch on your vial to the batch on the report.

1627580-64-6. It is printed in the specification table on this page so it can be checked against your own records before ordering.

Refrigerate (2-8 deg C) Lyophilized powder is the stable form; once reconstituted, a solution is far more fragile and should be aliquoted rather than repeatedly frozen and thawed.

>=99% by HPLC. The released figure for any given lot is on that lot's certificate rather than taken from this page, because purity is a property of a batch and not of a product line.

No. This is sold for laboratory research use only. It is not a drug, not a supplement, and not approved by the FDA for human or veterinary use. We do not provide dosing, administration, or protocol guidance, by phone, by email, or through the assistant on this site.

Mitochondrial Open Reading Frame of the 12S ribosomal RNA Type-c. The name describes its genomic origin: a short open reading frame located within the mitochondrial 12S rRNA gene rather than in the nuclear genome.

There is observational human data. Endogenous MOTS-c has been measured in human plasma, reported to decline with age in some cohorts, and reported to rise following exercise, and a mitochondrial DNA variant altering the peptide has been associated with longevity in specific populations. There is no published interventional human trial of administered MOTS-c and no human pharmacokinetic or safety data.

Not according to the proposed mechanism. The published model is indirect: MOTS-c is reported to inhibit methylenetetrahydrofolate dehydrogenase 2 in the folate one-carbon cycle, causing accumulation of AICAR, which is itself an endogenous AMPK activator. The peptide shifts a metabolic flux rather than binding the kinase.

The calculated free base molecular weight for MRWQEMGYIFYPRKLR is approximately 2174.6 g/mol. Higher figures on certificates typically reflect counterion content, usually acetate or trifluoroacetate retained from purification. It is the same molecule. Work from net peptide content rather than gross powder mass when concentration accuracy matters.

Oxidation of its two methionine residues, at positions one and six. Methionine sulfoxide formation is accelerated by air exposure, trace transition metals in buffers, and extended time in solution, and appears in mass spectrometry as a peak sixteen mass units above the parent. Minimizing agitation, using metal-free water, and aliquoting for single use are the practical controls.

Both are mitochondrial-derived peptides, meaning both are encoded within the mitochondrial genome rather than the nuclear genome. Humanin was identified first, in 2001, from the 16S ribosomal RNA gene region; MOTS-c was reported in 2015 from the 12S region. They have different sequences, different proposed mechanisms, and separate literatures.